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Opioids : past, present and future
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"FUTURE OPIOIDS
"If we could sniff or swallow something that would, for five or six hours each day, abolish our solitude as individuals, atone us with our fellows in a glowing exaltation of affection and make life in all its aspects seem not only worth living, but divinely beautiful and significant, and if this heavenly, world-transfiguring drug were of such a kind that we could wake up next morning with a clear head and an undamaged constitution - then, it seems to me, all our problems (and not merely the one small problem of discovering a novel pleasure) would be wholly solved and earth would become paradise." ALDOUS HUXLEY 1894 - 1963
THE BIRTH OF A NEW GENERATION A significant minority of the population only feel truly well on opioids. In effect, they self-medicate , taking responsibility for their own mental health in defiance of medical orthodoxy .
It would indeed be extraordinary if - alone among the neurotransmitter systems of the brain - the endogenous opioid families were immune from dysfunction. Enkephalins are critical to "basal hedonic tone" i.e. whether we naturally feel happy or sad. Yet the
therapeutic implications of a recognition that dysfunctional endogenous opioid systems underlie a spectrum of anxiety -disorders and depression are too radical - at present - for the medical establishment to contemplate. In consequence, the use of opioid -based pharmacotherapies for "psychological" pain is officially taboo. The unique efficacy of opioids in banishing mental distress is neglected. Their unrivalled efficacy in treating "physical" nociceptive pain is grudgingly accepted.
Later this century and beyond, however, the development of highly selective, site-specific designer drugs and innovative gene-therapies may enhance our native opioid function and revolutionise mental health . Therapeutic int"
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