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Electron Transfer Factors in Psychosis and Dyskinesia
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"Some key points in this review: radical-mediated
processes may involve specific biological messengers, later dubbed
"redox signaling". Second, homocysteine auto-oxidation produces oxidative stress,
relevant to the role of homocysteine in stroke and atherosclerosis. Likewise,
uric acid can be both an antioxidant and a pro-oxidant.
Similarly, polyacetylene organic semiconductors such as melanin can be "doped"
by charge-transfer agents. For a later version of this review, go here .
For more on homocysteine and redox signaling, go
here. For more on doped polyacetylenes go
here.
Physiol Chem. & Physics 4 (1972) 349-360
ELECTRON-TRANSFER FACTORS IN PSYCHOSIS AND DYSKINESIA
PETER PROCTOR
Department of Physics, The University of Texas at Houston, M.
D. Anderson Hospital and Tumor Institute, The University of Texas
at Houston Graduate School of Biomedical Sciences, Houston Texas
(Received May 17,1972)
SUMMARY
In man, chronic elevated systemic levels of compounds
possessing electron-transfer properties are typically associated
with one or more of a triad of characteristic. signs. These are
psychosis, dyskinesia, and abnormalities in pigmentation. The
possible in vivo interactions of such compounds are discussed.
INTRODUCTION
While there is strong indirect evidence for biological factors
in the etiology of the heterogeneous group of psychiatric
disorders known as "schizophrenia (1-3) and also in the
etiology of various movement disorders such as parkinsonism (4)
no single etiological factor has as yet been well defined in
either class- of disease.
A step in this direction is the work of Cotzias et al.(5)
reiterated by Curzon(4), -who noted an intriging correlation
between the chronic presence of substances having
electron-transfer properties, e.g., in phenothiazine treatment or
manganese poisoning, and t"
....
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