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NIAID Research on Thimerosal, NIAID Fact Sheet
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"March 2008
NIAID Research on Thimerosal
OVERVIEW
Mercury is a naturally occurring chemical element found throughout the
environment. Mercury is found in three forms: as a pure metal (as found
in thermometers), as inorganic salts, and as an organic derivative. Humans
and wildlife are exposed to all three forms. Most environmental mercury
consists of the metallic and inorganic forms. Because mercury is everywhere,
it is not possible to prevent all exposure to it. High levels of mercury,
however, are toxic.
Methyl mercury, the most common organic derivative of mercury, is mainly
produced by microorganisms in water and soil. Methyl mercury is of particular
concern because it can accumulate in certain edible freshwater and saltwater
fish, especially in larger and older fish, to levels that are much greater
than levels in the surrounding water. Methyl mercury also can accumulate
in humans who eat these fish. Exposure to high levels of methyl mercury
is toxic and can cause mental retardation, cerebral palsy, and seizures.
The fetus is especially sensitive to methyl mercury exposure and may suffer
brain damage or even death if exposed to high levels.
Since the 1930s, thimerosal has been added to some vaccines and other
products because it is effective in killing bacteria and in preventing
bacterial contamination, particularly in multidose containers. When thimerosal
is degraded or metabolized, one product is ethyl mercury, another organic
derivative of mercury. Not much is known about the effects of thimerosal
exposure on humans and how this compares to methyl mercury exposure. The
only known side effects of receiving low doses of thimerosal in vaccines
have been minor reactions such as redness and swelling at the injection"
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