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MDMA / Ecstasy : Utopian Pharmacology
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"UTOPIAN PHARMACOLOGY Mental Health in the Third Millennium
MDMA and Beyond
MDMA/Ecstasy
A brief history of MDMA
The MDMA Experience
MDMA : neurotoxicity
MDMA : neuroprotection
Ecstasy for life?
The molecular machinery of magic
Post-Darwinian Medicine
Beyond MDMA : mental superhealth
MDMA/Ecstasy Can safe, sustainable analogues of MDMA
be developed? There is an urgent need for non-neurotoxic empathogens
and entactogens suitable
for lifelong use. Alas no single "magic bullet" yet exists that replicates the
subjective effects of MDMA on a long-term basis. Hence most of us are doomed to
display the quasi-psychopathic indifference to each other characteristic of the
MDMA-naïve state.
A brief history of MDMA
MDMA [3,4-methylenedioxy-methamphetamine: ' Ecstasy '] was first 1 synthesized in 1912 by the German pharmaceutical company Merck . MDMA was patented in Darmstadt, Germany on May 16th 1914, issue number 274,350; and promptly forgotten. Merck's researchers had no idea of the significance of what they had done. Merck were searching for a good vasoconstrictor, a styptic to reduce bleeding. In 1912 two of their chemists, G. Mannish and W. Jacobsohn, created MDMA as a by-product while attempting to synthesise hydrastinin. MDMA is listed on Merck's patent-application merely as a chemical intermediate "for products of potential pharmaceutical value".
MDMA surfaced again briefly
as one of a number of agents used in clandestine US military research during the
1950s. The CIA 's Project MK-Ultra was investigating
new techniques of brainwashing, espionage and mind-control. MDMA, code-named EA-1475,
was tested at the US Army's Edgewood Arsenal in Maryland. However, unlike LSD
or the ill-named "truth drug" scopolamine ,
MDMA was used only on non-human animals: mice, rats, pigs, monkeys and "
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